Latex is a natural product obtained from rubber trees. Sensitization and subsequent exposure to latex products can lead to allergic (immediate hypersensitivity) reactions including anaphylaxis. Gloves are the largest source of latex exposure, and the majority of serious latex reactions occur in medical settings. Allergen testing and avoidance in history positive or high risk groups (medical personnel, spina bifida patients and rubber workers) is presently the best treatment option.