The APC gene product and colorectal carcinogenesis.
Copyright policy )The APC gene product and colorectal carcinogenesis.
The adenomatous polyposis coli (APC) gene has been found to be mutated during the development of sporadic colorectal tumours as well as in familial adenomatous polyposis patients (FAP), mutations being somatic or germinal respectively. The gene product is truncated in the carboxyterminal region but the role of the APC protein in tumorigenesis is not well understood. The purpose of this review is to reassess studies on the APC protein in an attempt to understand how the loss of its functions may cause or contribute to the development of carcinomas.
Adenomatous Polyposis Coli Protein, Cell Cycle, Proteins, Apoptosis, Gene Expression Regulation, Neoplastic, Cytoskeletal Proteins, Adenomatous Polyposis Coli, Trans-Activators, Humans, Colorectal Neoplasms, Microtubule-Associated Proteins, beta Catenin
Adenomatous Polyposis Coli Protein, Cell Cycle, Proteins, Apoptosis, Gene Expression Regulation, Neoplastic, Cytoskeletal Proteins, Adenomatous Polyposis Coli, Trans-Activators, Humans, Colorectal Neoplasms, Microtubule-Associated Proteins, beta Catenin
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