Evaluation and treatment of pediatric condylomata acuminata are challenging problems. Careful and thorough evaluation for the possibility of sexual abuse is mandatory in all cases. New molecular techniques of HPV DNA detection and typing have not proved helpful in determining the source of the infection but may assist in identifying children who are at risk for the development of carcinoma. Ideal therapy does not exist; non-intervention may be the most appropriate choice for the majority of patients who carry low-risk viral types. Many unanswered questions remain regarding the biology and epidemiology of HPV in children and adults. Clinical and basic science research specifically designed to address the concerns of the pediatric age group is urgently needed.