Radioligand binding studies on some dihydropyridine analogues as probes of the dihydropyridine receptor.
Copyright policy )Radioligand binding studies on some dihydropyridine analogues as probes of the dihydropyridine receptor.
The affinity of two compounds, closely related to 1,4-dihydropyridines, was determined in competition binding experiments using canine cerebral cortex membranes and [3H]nitrendipine as a radioligand. Some aspects of structure-affinity relationships are discussed in relation to existing models of the dihydropyridine binding site.
- Comenius University Slovakia
Cerebral Cortex, Male, Dihydropyridines, Calcium Channels, L-Type, Nitrendipine, Nerve Tissue Proteins, In Vitro Techniques, Calcium Channel Blockers, Models, Biological, Radioligand Assay, Structure-Activity Relationship, Dogs, Animals, Calcium Channels
Cerebral Cortex, Male, Dihydropyridines, Calcium Channels, L-Type, Nitrendipine, Nerve Tissue Proteins, In Vitro Techniques, Calcium Channel Blockers, Models, Biological, Radioligand Assay, Structure-Activity Relationship, Dogs, Animals, Calcium Channels
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