Immunocytochemical localization of myotonin protein kinase on muscle from patients with congenital myotonic dystrophy.
Copyright policy )Immunocytochemical localization of myotonin protein kinase on muscle from patients with congenital myotonic dystrophy.
Using a polyclonal anti myotonin-protein kinase (M-PK) antibody against synthetic M-PK peptides corresponding to part of the amino acid sequence, and the immunohistochemical analysis of indirect immunoperoxidase, we have investigated localization of M-PK on muscle from patients with congenital myotonic dystrophy. In congenital myotonic dystrophy (MD) patients, one month and 3 months old, M-PK was weakly expressed at sarcolemma of muscle fibers. In congenital MD patients from 2 to 9 years of age, M-PK was clearly expressed at sarcolemma of muscle fibers. M-PK of immature muscle is weakly expressed at sarcolemma. With aging, M-PK is clearly expressed at sarcolemma of muscle from MD patient and normal control.
- University of Murcia Spain
- Sapporo Medical University Japan
Adult, Male, CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología, :6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], Muscle Fibers, Skeletal, Protein Serine-Threonine Kinases, Myotonin-Protein Kinase, Deoxyribonuclease EcoRI, Immunoenzyme Techniques, Myotomin dystrophy, Humans, Myotonic Dystrophy, Child, Muscle, Skeletal, Alleles, Infant, DNA, Immunohistochemistry, Blotting, Southern, Myotonin protein kinase, Child, Preschool, Female, Protein Kinases, Polymorphism, Restriction Fragment Length
Adult, Male, CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología, :6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], Muscle Fibers, Skeletal, Protein Serine-Threonine Kinases, Myotonin-Protein Kinase, Deoxyribonuclease EcoRI, Immunoenzyme Techniques, Myotomin dystrophy, Humans, Myotonic Dystrophy, Child, Muscle, Skeletal, Alleles, Infant, DNA, Immunohistochemistry, Blotting, Southern, Myotonin protein kinase, Child, Preschool, Female, Protein Kinases, Polymorphism, Restriction Fragment Length
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