An overview is given of the technical aspects and the diagnostic usefulness of liver biopsy. From the clinical side, the procedures for taking liver biopsies and the various types of biopsy are summarized. The histopathology section mentions precautions for tissue sampling and processing, and reviews the diagnostically useful techniques and special microscopy procedures. Consideration is given to the factors which determine the accuracy of histopathological diagnosis, both those relating to the tissue specimen and those relating to the interpreter. Published studies on quantitation and semi-quantitation of liver biopsy findings and their reproducibility are mentioned, with a final remark on the contribution of liver biopsy to diagnosis and therapy. Emphasis is placed throughout on the necessity for close collaboration between clinician and pathologist.