Molecular basis of T lymphocyte CD4 antigen functions.

M, Gaubin; M, Autiero; R, Houlgatte; S, Basmaciogullari; C, Auffray; D, Piatier-Tonneau

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Article . 1997

Data sources: Europe PubMed Central

Molecular basis of T lymphocyte CD4 antigen functions.

descriptionPublicationkeyboard_double_arrow_right Article 06 Feb 1997 English Journal:European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, volume 34 (issn: 0939-4974,

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Authors: M, Gaubin; M, Autiero; R, Houlgatte; S, Basmaciogullari; C, Auffray; D, Piatier-Tonneau;

pmid: 8891524

Molecular basis of T lymphocyte CD4 antigen functions.

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Abstract

The T cell surface antigen CD4 plays a pivotal role in the MHC class II-restricted response of specific T lymphocytes and serves as the major receptor of human immunodeficiency viruses (HIV). Recent studies have shown the high complexity of CD4 functions in physiological and pathological conditions. We report here a short review of recent developments in the field and discuss the structural features which regulate the functions mediated by the CD4 coreceptor in mature T lymphocytes.

Keywords

Models, Molecular, Binding Sites, CD4 Antigens, HIV-1, Histocompatibility Antigens Class II, Humans, HIV Envelope Protein gp120

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