[Clinical usefulness of serum CYFRA21-1 in colorectal cancer].

T, Miyashita; G, Nishimura; Y, Michiwa; T, Sato; K, Tsugawa; S, Fushida; K, Sugiyama; T, Fujimura; Y, Yonemura; K, Miwa; I, Miyazaki

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Article . 1996

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[Clinical usefulness of serum CYFRA21-1 in colorectal cancer].

descriptionPublicationkeyboard_double_arrow_right Article 21 Nov 1996 Japanese Journal:Gan to kagaku ryoho. Cancer & chemotherapy, volume 23 (issn: 0385-0684,

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Authors: T, Miyashita; G, Nishimura; Y, Michiwa; T, Sato; K, Tsugawa; S, Fushida; K, Sugiyama; +4 Authors

pmid: 8886047

[Clinical usefulness of serum CYFRA21-1 in colorectal cancer].

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Abstract

Serum CYFRA21-1 levels were studied in 127 cases of colorectal cancer. The positive rates for serum CYFRA21-1 were 34.6% in primary colorectal cancer. There was a significant correlation between the positive rates of serum CYFRA21-1 and liver metastases, peritoneal dissemination, lymph node metastases, or clinical stage. The survival rate for patients in the CYFRA21-1 positive group was lower than those with CYFRA21-1 negative group. Among patients who underwent curative operation, patients is the CYFRA21-1 positive group gave a recurrence rate of 26.6%, against 9.4% in the CYFRA21-1 negative group. There was no correlation between serum CYFRA21-1 levels and serum CEA levels. These findings suggest that Serum CYFRA21-1 levels may be a useful indicator in estimating the prognosis for colorectal cancer.

Related Organizations

Kanazawa University
Japan

Keywords

Rectal Neoplasms, Liver Neoplasms, Antibodies, Monoclonal, Adenocarcinoma, Prognosis, Survival Rate, Lymphatic Metastasis, Colonic Neoplasms, Biomarkers, Tumor, Humans, Keratins, Neoplasm Invasiveness

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