Neonatal meningitis caused by Alcaligenes xylosoxidans is associated with a high mortality rate. The causative microorganism is resistant to most antimicrobials. Generally, once the organism has been isolated from the cerebrospinal fluid of the infected neonate, initial therapy with a third-generation cephalosporin and trimethoprim-sulfamethoxazole is recommended before determining its susceptibility to antimicrobials. There present this is the first of neonatal meningitis with transient diabetes insipidus cause by A. xylosoxidans. The patient was treated with dDAVP for seven days and a combination of imipenem plus trimethoprim-sulfamethoxazole for 28 days. The patient was discharged in a stable condition and the end of that time, but with sequelae of hydrocephalus and hearing impairment.