To evaluate the different therapies for penile induration. The results achieved in our series of 280 patients are described and the literature reviewed.The study analyzed 2,752 cases of the literature that had been treated with Potaba, 1420 treated with radiotherapy, 117 cases treated with Orgotein injection and 93 cases that had been treated by surgery (a malleable prosthesis had been implanted 53 patients).In 2,752 cases of the literature that had been treated with Potaba, an improvement was seen in 60% (range 10%-82%) and the median failure rate was 40%. The overall success rate in 117 cases treated with Orgotein was 63%, with a median failure rate of 37%. In 1420 cases that had been treated with radiotherapy, the improvement and failure rates were 60% and 40%, respectively. In 93 patients that had undergone surgery, the improvement rate was 80%. Excellent results were achieved in all but 2 of the 53 patients in whom a malleable prosthesis had been implanted (infection required explantation of the prosthesis in these 2 patients).The importance of performing a detailed study of the plaque is underscored. A predisposition for abnormal scar tissue formation has to be considered. If surgery is indicated, the correct choice of surgical technique can achieve excellent results.