Specific proteolysis of ceruloplasmin by leukocyte elastase.

Name: Specific proteolysis of ceruloplasmin by leukocyte elastase.
Creator: Q A, Sang
Keywords: 0301 basic medicine, 0303 health sciences, Pancreatic Elastase, Swine, Hydrolysis, Molecular Sequence Data, Ceruloplasmin, 3. Good health, Substrate Specificity, Molecular Weight

Q A, Sang

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Article . 1996

Data sources: Europe PubMed Central

Specific proteolysis of ceruloplasmin by leukocyte elastase.

descriptionPublicationkeyboard_double_arrow_right Article 17 Apr 1996 English Journal:Biochemistry and molecular biology international, volume 37 (issn: 1039-9712,

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Authors: Q A, Sang;

pmid: 8595398

Specific proteolysis of ceruloplasmin by leukocyte elastase.

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Abstract

Ceruloplasmin (Cp) is a major copper transporting plasma protein. The susceptibility of porcine Cp by human leukocyte elastase and plasmin has been investigated. The 116 and 48 kDa bands induced by both proteinases have the same N-terminal sequences which are identical to that of the 132 kDa Cp species, KDKHYYIGIVET. The 70 kDa band generated by elastase has a N-terminal sequence of IGGKVVVYYYIA, and the 68 kDa band generated by plasmin has that of TIIEDAIVGKKV. The 19 kDa bands produced by elastase and plasmin have N-terminal sequences of FNPIKNLLFFLL and VFNPIKNLLFFL, respectively. The novel observations suggest that, in addition to plasmin, leukocyte elastase may play a role in angiogenesis and inflammation by digesting Cp.

Related Organizations

Florida Southern College
United States

Keywords

Pancreatic Elastase, Swine, Hydrolysis, Molecular Sequence Data, Ceruloplasmin, Substrate Specificity, Molecular Weight, Leukocytes, Animals, Humans, Amino Acid Sequence, Leukocyte Elastase

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