Regulation of viral and cellular gene expression in sensory neurons.
Copyright policy )Regulation of viral and cellular gene expression in sensory neurons.
Herpes simplex virus (HSV) establishes latent infections of neuronal cells but replicates readily in other cell types. This effect is dependent upon the presence of the inhibitory cellular transcription factor Oct-2 in neuronal cells. This factor inhibits the viral immediate-early gene promoters by at least two distinct mechanisms. The significance of Oct-2 in regulating viral and cellular gene expression in sensory neurons is discussed.
- University College London United Kingdom
Gene Expression Regulation, Viral, Base Sequence, Molecular Sequence Data, Virus Replication, Rats, DNA-Binding Proteins, Gene Expression Regulation, Cricetinae, Ganglia, Spinal, DNA, Viral, Animals, Simplexvirus, Neurons, Afferent, Octamer Transcription Factor-2, Promoter Regions, Genetic, Genes, Immediate-Early, Cell Line, Transformed, Transcription Factors
Gene Expression Regulation, Viral, Base Sequence, Molecular Sequence Data, Virus Replication, Rats, DNA-Binding Proteins, Gene Expression Regulation, Cricetinae, Ganglia, Spinal, DNA, Viral, Animals, Simplexvirus, Neurons, Afferent, Octamer Transcription Factor-2, Promoter Regions, Genetic, Genes, Immediate-Early, Cell Line, Transformed, Transcription Factors
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