
The BTB/POZ domain defines a newly characterized protein-protein interaction interface. It is highly conserved throughout metazoan evolution and generally found at the NH2 terminus of either actin-binding or, more commonly, nuclear DNA-binding proteins. By mediating protein binding in large aggregates, the BTB/POZ domain serves to organize higher order macromolecular complexes involved in ring canal formation or chromatin folding.
Sequence Homology, Amino Acid, Microfilament Proteins, Molecular Sequence Data, Nuclear Proteins, Zinc Fingers, Chromatin, Protein Structure, Tertiary, DNA-Binding Proteins, Structure-Activity Relationship, Viral Proteins, Animals, Drosophila, Amino Acid Sequence
Sequence Homology, Amino Acid, Microfilament Proteins, Molecular Sequence Data, Nuclear Proteins, Zinc Fingers, Chromatin, Protein Structure, Tertiary, DNA-Binding Proteins, Structure-Activity Relationship, Viral Proteins, Animals, Drosophila, Amino Acid Sequence
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