[Mefloquine and sulfadoxine/pyrimethamine overdose in malaria tropica].
Copyright policy )[Mefloquine and sulfadoxine/pyrimethamine overdose in malaria tropica].
A 39 year-old man with malaria due to Plasmodium falciparum received 3500 mg mefloquine over 3 days, in addition to 3250 mg chloroquine and 175/3500 mg sulfadoxine/pyrimethamine. He developed severe neuropsychiatric symptoms and had to be hospitalized. Treatment with diazepam, haloperidol and thioridazine achieved relief of the severe symptoms after 4 days. The patient was still suffering from discrete neuropsychiatric symptoms 8 months after treatment.
Adult, Male, Diazepam, Dose-Response Relationship, Drug, Thioridazine, Drug Administration Schedule, Psychoses, Substance-Induced, Mefloquine, Pyrimethamine, Sulfadoxine, Haloperidol, Humans, Drug Therapy, Combination, Malaria, Falciparum
Adult, Male, Diazepam, Dose-Response Relationship, Drug, Thioridazine, Drug Administration Schedule, Psychoses, Substance-Induced, Mefloquine, Pyrimethamine, Sulfadoxine, Haloperidol, Humans, Drug Therapy, Combination, Malaria, Falciparum
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