Gamma delta T-cell development.
Copyright policy )Gamma delta T-cell development.
Gamma delta T cells consist of multiple lineages of cells with distinct antigen receptor repertoires, tissue localization and function. Recent evidence suggests that the ordered appearance of these sublineages during development is a result of programmed rearrangement of V gamma-gene segments. It appears that the T-cell receptor repertoire, at least of the gamma delta T cells with invariant receptors, is the result of site-directed rearrangement and cellular selection does not play a major role.
- University of California, Berkeley United States
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor, Gene Rearrangement, delta-Chain T-Cell Antigen Receptor, Cell Differentiation, Receptors, Antigen, T-Cell, gamma-delta, Thymus Gland, Models, Biological, Mice, Mutant Strains, Mice, T-Lymphocyte Subsets, Animals, Signal Transduction
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor, Gene Rearrangement, delta-Chain T-Cell Antigen Receptor, Cell Differentiation, Receptors, Antigen, T-Cell, gamma-delta, Thymus Gland, Models, Biological, Mice, Mutant Strains, Mice, T-Lymphocyte Subsets, Animals, Signal Transduction
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