Candida albicans, an ubiquity yeast, has several properties which allow it colonize and invade host tissues, often resisting eradication. Acid proteinase is the virulence factor. Bacterial proteinases are widely used in the detergent industry and the role of occupational exposure to enzymes in the development of mucocutaneous candidosis warrants investigation. A case of candidosis is reported in a worker employed in a detergent factory in whom there was no evidence of any kind of immunosuppression. The relationship between occupational exposure and illness is analyzed.