[Fetal chromosome abnormalities diagnosed by chorionic villi sampling].

Chorionic villus sampling was performed for chromosome analysis in 387 cases during a 4-year-period. In 115 cases transcervical while in 272 cases transabdominal sampling was carried out. Chromosomal abnormalities were found in 25 cases (6.4%). Autosomal trisomies occurred in 17 cases, structural anomalies in 2 cases and sex chromosomal aberrations in 6 cases. The pregnancy was terminated in 19 cases because of chromosome abnormality, in 5 further cases because of X-linked disease and male fetus. After transcervical sampling spontaneous abortion occurred in 7 cases (5.8%), while after transabdominal sampling in 8 cases (2.8%). The authors prefer in their practice the early transabdominal CVS, which can be performed safety already at the end of the first trimester.

Keywords

Chromosome Aberrations, Male, X Chromosome, Chromosome Disorders, Trisomy, Pregnancy Trimester, First, Chorionic Villi Sampling, Pregnancy, Prenatal Diagnosis, Humans, Female, Sex Chromosome Aberrations

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