The Unp proto-oncogene encodes a nuclear protein.
Copyright policy The Unp proto-oncogene encodes a nuclear protein.
The mouse Unp gene is related to TRE17, a human oncogene, but is not its mouse homolog. Unp is a ubiquitously expressed gene producing two related mRNAs. The protein product of Unp is localized in the nucleus. Expression of Unp from a highly active promoter results in tumorigenic transformation of NIH3T3 cells injected into athymic mice. Unp therefore encodes a novel nuclear oncoprotein.
- University of Ottawa Canada
Oncogene Proteins, Molecular Sequence Data, Mice, Nude, Nuclear Proteins, 3T3 Cells, Proto-Oncogene Mas, Mice, Proto-Oncogene Proteins, Proto-Oncogenes, Animals, Amino Acid Sequence, Ubiquitin-Specific Proteases, Ubiquitin Thiolesterase
Oncogene Proteins, Molecular Sequence Data, Mice, Nude, Nuclear Proteins, 3T3 Cells, Proto-Oncogene Mas, Mice, Proto-Oncogene Proteins, Proto-Oncogenes, Animals, Amino Acid Sequence, Ubiquitin-Specific Proteases, Ubiquitin Thiolesterase
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