Immediate and long-term responses to pelotherapy were evaluated in 80 patients with ischemic heart disease (IHD) combined with osteochondrosis. The effect was registered in 75-82% of the IHD patients with painless disease or angina pectoris functional class II and III. The clinical improvement was confirmed by 24-hour ECG monitoring findings and bicycle ergometry results. The effect persisted for 12 months in the majority of patients with IHD functional class II and with painless IHD, but only in 15% of those with IHD functional class III. Contraindications to peloids are specified.