[Properties of polyreactive immunoglobulins].

S A, Bobrovnik; A V, Marinets

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Article . 1994

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[Properties of polyreactive immunoglobulins].

descriptionPublicationkeyboard_double_arrow_right Article 18 May 1994 Russian Journal:Ukrainskii biokhimicheskii zhurnal (1978), volume 65 (issn: 0201-8470,

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Authors: S A, Bobrovnik; A V, Marinets;

pmid: 8160292

[Properties of polyreactive immunoglobulins].

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Abstract

Some biological properties of polyreactive antibodies (PRABs) from the serum of mice, rabbit and cattle are investigated. Optimal parameters of the activation process are determined. It is shown that solution of KSCN (potassium rhodanide) more effectively impedes interaction of PRABs with the antigen on the immunological plate than interaction between specific antibodies. Dynamics of binding of PRABs and affine-purified antibodies to an immobilized antigen is analyzed. The competitive ELISA shows the absence of specificity of PRABs and their less avidity in comparison with the usual antibodies. It is supposed that PRABs play an essential role in the immune system of animals and man.

Keywords

Antigen-Antibody Reactions, Mice, Antibody Specificity, Animals, Immunoglobulins, Cattle, Enzyme-Linked Immunosorbent Assay, Rabbits

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