Hypertension resistant to pharmacological treatment may be caused by various factors. Next to the real refractory forms, there is one of false resistance known as "pseudoresistance". Pseudoresistance is a condition with a discrepancy between blood pressure values measured at the physician's office, which appear falsely high, compared to those measured at home by the patient or with the 24-hour ambulatory blood pressure monitoring which appear to be within the normal range. We have studied 10 pseudoresistant patients and valued their average pressures measured at the doctor's office (158/96 mmHg), comparing them with those measured at home by the patients or family members (135/83 mmHg) and with those measured with 24 hour PA monitoring with Takeda monitor mod. 2420 (average values of daytime pressure 129/79 mmHg). The difference between values at the physician's office and those measured with the 24 hour ambulatory blood pressure monitoring have resulted statistically significant (p < 0.0001). In all those patients with hypertension treated pharmacologically we recommend the use of 24 hour ambulatory blood pressure monitoring, so as to evaluate realistically the efficacy of the therapy itself and to identify other potential "pseudoresistant" individuals.