Murine hybridomas secreting monoclonal antibodies reacting with Mlsa antigens.
Copyright policy )Murine hybridomas secreting monoclonal antibodies reacting with Mlsa antigens.
Murine monoclonal antibodies have been developed from spleens of AKR mice hyperimmunised with the monoclonal antibody against TCR-V beta 6. Two new monoclonal antibodies called AL-12-3 and AL-32-7 were able to specifically block Mlsa-induced but not MHC-induced mixed lymphocyte responses in a dose-dependent manner. Both antibodies are mouse IgG3 lambda chain isotype and bind to Mlsa-bearing lymphocytes from different strains of mice. The availability of such antibodies may well facilitate future research aimed at immunochemical and molecular characterization of Mls determinants.
- Guy's and St Thomas' NHS Foundation Trust United Kingdom
- St Thomas' Hospital United Kingdom
Mice, Inbred BALB C, Hybridomas, Receptors, Antigen, T-Cell, alpha-beta, Antibodies, Monoclonal, In Vitro Techniques, Binding, Competitive, Minor Lymphocyte Stimulatory Antigens, Rats, Mice, Mice, Inbred AKR, Immunoglobulin G, Animals, Immunization, Lymphocyte Culture Test, Mixed
Mice, Inbred BALB C, Hybridomas, Receptors, Antigen, T-Cell, alpha-beta, Antibodies, Monoclonal, In Vitro Techniques, Binding, Competitive, Minor Lymphocyte Stimulatory Antigens, Rats, Mice, Mice, Inbred AKR, Immunoglobulin G, Animals, Immunization, Lymphocyte Culture Test, Mixed
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