Visualization of damaged brain tissue after ischemic stroke with cobalt-55 positron emission tomography.
Copyright policy )Visualization of damaged brain tissue after ischemic stroke with cobalt-55 positron emission tomography.
In animal experiments, the radionuclide 55Co2+ has been shown to accumulate in degenerating cerebral tissue similar to Ca2+.The potential role of 55Co2+ for in vivo brain PET imaging was investigated in four patients after ischemic stroke.PET showed uptake of 55Co2+ in damaged brain tissue irrespective of blood-brain barrier integrity, as affirmed by CT and MRI.Our preliminary results indicate that 55CoCl2 may prove to be a useful and relatively inexpensive PET radiopharmaceutical for visualization of degenerative processes in brain tissue.
- University Medical Center Groningen Netherlands
- University of Groningen Netherlands
Male, KAINATE RECEPTORS, Brain, Middle Aged, Magnetic Resonance Imaging, Brain Ischemia, PET, ISCHEMIC DAMAGE, Blood-Brain Barrier, COBALT, Humans, Female, Cobalt Radioisotopes, Tomography, X-Ray Computed, NEURONS, STROKE, GLIAL-CELLS, Aged, Tomography, Emission-Computed
Male, KAINATE RECEPTORS, Brain, Middle Aged, Magnetic Resonance Imaging, Brain Ischemia, PET, ISCHEMIC DAMAGE, Blood-Brain Barrier, COBALT, Humans, Female, Cobalt Radioisotopes, Tomography, X-Ray Computed, NEURONS, STROKE, GLIAL-CELLS, Aged, Tomography, Emission-Computed
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