
The human genome contains a large number of endogenous retroviral-related sequences. While the function of these sequences is unknown, they may contribute to disease processes through their regions of homology with infectious retroviruses. We have been further characterizing a recently reported HTLV-1 related endogenous retroviral sequence cloned from T lymphocytes isolated from a patient with essential cryoglobulinemia. We here report further detailed transcriptional analysis of the sequence for tissue and cell-cycle specificity and a novel finding of an association between the endogenous retrovirus and a ras-related gene.
Base Sequence, Genes, Viral, Transcription, Genetic, Cell Cycle, Molecular Sequence Data, Oncogenes, Blotting, Southern, Genes, ras, Retroviridae, Tumor Cells, Cultured, Humans, Polymorphism, Restriction Fragment Length, Cell Line, Transformed
Base Sequence, Genes, Viral, Transcription, Genetic, Cell Cycle, Molecular Sequence Data, Oncogenes, Blotting, Southern, Genes, ras, Retroviridae, Tumor Cells, Cultured, Humans, Polymorphism, Restriction Fragment Length, Cell Line, Transformed
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