immunoperturbation in paraproteinemia.
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The immunoperturbations in paraproteinemias are due predominantly to a disturbance of the B-cell system. The immunologic deficiency is characterized clinically by an increased susceptibility to infections and serologically by a reduction of the nonmyeloma immunoglobulins. In advances cases the capacity to produce specific antibodies is impaired. This may be attributed to a low rate of synthesis or an increased catabolism of normal immunoglobulins.
B-Lymphocytes, Blood Protein Disorders, Bone Marrow Cells, Middle Aged, Immunoglobulin A, Intestinal Diseases, Myeloma Proteins, Immunoglobulin M, Bone Marrow, Immunoglobulin G, Sepsis, Humans, Waldenstrom Macroglobulinemia, Multiple Myeloma, Respiratory Tract Infections
B-Lymphocytes, Blood Protein Disorders, Bone Marrow Cells, Middle Aged, Immunoglobulin A, Intestinal Diseases, Myeloma Proteins, Immunoglobulin M, Bone Marrow, Immunoglobulin G, Sepsis, Humans, Waldenstrom Macroglobulinemia, Multiple Myeloma, Respiratory Tract Infections
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