[Exogenous phosphocreatine in the prevention and treatment of cardiac insufficiency in patients with myocardial infarction].

N B, Perepech; A O, Nedoshivin; A E, Kutuzova

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Clinical Medicine (R...arrow_drop_down

Clinical Medicine (Russian Journal)

Article . 1994

Data sources: Europe PubMed Central

[Exogenous phosphocreatine in the prevention and treatment of cardiac insufficiency in patients with myocardial infarction].

descriptionPublicationkeyboard_double_arrow_right Article 30 Aug 1994 Russian Journal:Klinicheskaia meditsina, volume 71 (issn: 0023-2149,

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Authors: N B, Perepech; A O, Nedoshivin; A E, Kutuzova;

pmid: 8046897

[Exogenous phosphocreatine in the prevention and treatment of cardiac insufficiency in patients with myocardial infarction].

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Abstract

Central, intracardiac hemodynamics and myocardial contractility were assessed in 97 inpatients with macrofocal myocardial infarction. Of them, 71 received conventional chemotherapy versus 26 patients given additionally intravenous phosphocreatine (neoton). The total dose of neoton 30 g was injected during the course of 6 days following the disease onset. With minimal changes in central hemodynamics, phosphocreatine was found to prevent left-ventricular dilatation and development of congestive heart failure by decreasing preload, to maintain myocardial contractility without reduction.

Keywords

Adult, Male, Phosphocreatine, Cardiac Output, Low, Hemodynamics, Myocardial Infarction, Middle Aged, Myocardial Contraction, Ventricular Function, Left, Injections, Intravenous, Humans, Aged

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