Familial CREST syndrome.
Copyright policy )Familial CREST syndrome.
The familial occurrence of scleroderma is uncommon particularly the limited (CREST) form. We describe 2 families in which such an association occurred. Family pedigree 1 consists of 2 of 3 sisters with CREST scleroderma. Both affected sisters shared HLA types and C4 allotypes including DR5, found more frequently in patients with scleroderma. The unaffected sister did not share this MHC allele. Family pedigree 2 includes a grandmother and grandson with CREST scleroderma as well as a family member with Raynaud's phenomena alone. We conclude that familial occurrence of scleroderma may be associated with shared class II MHC antigens.
- University of Queensland Australia
- University of Melbourne Australia
- University of Queensland Australia
- Austin Hospital Australia
- Austin Health Australia
Adult, CREST Syndrome, Genetic Markers, Male, 2403 Immunology, 2745 Rheumatology, familial, CREST, HLA-DR5 Antigen, Pedigree, HLA, HLA Antigens, 2723 Immunology and Allergy, Humans, scleroderma, Female, Aged
Adult, CREST Syndrome, Genetic Markers, Male, 2403 Immunology, 2745 Rheumatology, familial, CREST, HLA-DR5 Antigen, Pedigree, HLA, HLA Antigens, 2723 Immunology and Allergy, Humans, scleroderma, Female, Aged
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!