Staurosporine and gossypol are inhibitors of the function of peptide elongation factor 1 alpha from rabbit reticulocytes.
Copyright policy )Staurosporine and gossypol are inhibitors of the function of peptide elongation factor 1 alpha from rabbit reticulocytes.
As it has been found, the incubation of [gamma-32P]ATP with elongation factor--1 alpha purified from rabbit reticulocytes resulted in the phosphorylation of several substrate proteins /Tuhácková, Z. (1992) In: Rec. Adv. Cell. Mol. Biol. 4, 79-86, Peeters Press, Leuven/ (1). In the present paper chromatofocusing of the purified eEF-1 alpha demonstrates that the ATP-dependent protein kinase activity is associated with a single protein catalyzing the GTP-dependent binding of aminoacyl-tRNA to ribosomes. Both of these activities are inhibited by staurosporine and gossypol. The inhibition by GDP but not by GTP indicates a possible involvement of conformation changes also in the modulation of the protein kinase activity displayed by eEF-1 alpha.
Reticulocytes, Gossypol, Chromatography, Ion Exchange, Peptide Elongation Factors, Staurosporine, Guanosine Diphosphate, Chromatography, Affinity, Histones, Molecular Weight, Kinetics, Alkaloids, Peptide Elongation Factor 1, Animals, Electrophoresis, Polyacrylamide Gel, Rabbits, Phosphorylation, Ribosomes, Protein Kinase C
Reticulocytes, Gossypol, Chromatography, Ion Exchange, Peptide Elongation Factors, Staurosporine, Guanosine Diphosphate, Chromatography, Affinity, Histones, Molecular Weight, Kinetics, Alkaloids, Peptide Elongation Factor 1, Animals, Electrophoresis, Polyacrylamide Gel, Rabbits, Phosphorylation, Ribosomes, Protein Kinase C
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!