The authors report the isolation of the basidiomycete Schizophyllum commune in two enclosed areas of healthy facilities in the city of Panama. The growth occurred in Sabouraud's agar as a white mycelium which gradually rose above the surface of the culture medium until it became a fan-shaped basidiocarp. This basidiomycete is found in environmental samples, but since there have been reports of its role in pathologic processes it should be included in the etiologic differential diagnosis in some patients and clinical laboratory must identify it and not discard it as a "contaminant".