In the absence of active pulmonary disease, hepatic focal tuberculosis is a rare form of tuberculosis. We present a case of pseudotumoral hepatic tuberculosis in a 44-year-old man; diagnosis is difficult because of its radiological similarity with primary or metastatic hepatic cancer. Percutaneous biopsy with US or CT guidance offers a good diagnostic alternative to laparoscopy. Histology examination revealed a tuberculoid granulomatous lesion. The disease has a good response to tuberculostatic treatment.