[Nucleotide sequence analysis of SHV-2 beta-lactamase gene in Enterobacter gergoviae].

Y, Cheng; M, Chen

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ACTA MICROBIOLOGICA SINICA

Article . 1994

Data sources: Europe PubMed Central

[Nucleotide sequence analysis of SHV-2 beta-lactamase gene in Enterobacter gergoviae].

descriptionPublicationkeyboard_double_arrow_right Article 13 Dec 1994Journal:Wei sheng wu xue bao = Acta microbiologica Sinica, volume 34 (issn: 0001-6209,

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Authors: Y, Cheng; M, Chen;

pmid: 7975558

[Nucleotide sequence analysis of SHV-2 beta-lactamase gene in Enterobacter gergoviae].

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Abstract

The extended-spectrum beta-lactamase (ESbla) gene on R-plasmid harbored in E. coli C3773, a transconjugant of the clinical isolate of Ent. gergoviae 3773 from our hospital, was cloned and two fragments were subcloned into M13. The nucleotide sequences of two fragments were determined. The primary structure of this ESbla deduced from nucleotide sequence had only a Gly-->Ser change at position 234 in comparison with SHV-1, which was supposed to be responsible for extended-spectrum activity and resistance to 3rd generation cephalosporins. The result suggested that the ESbla appearing in our hospital was SHV-2.

Related Organizations

Chinese Academy of Medical Sciences & Peking Union Medical College
China (People's Republic of)
Peking Union Medical College Hospital
China (People's Republic of)

Keywords

Genes, Bacterial, R Factors, Enterobacter, Point Mutation, Drug Resistance, Microbial, Sequence Analysis, beta-Lactamases, Cephalosporins

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