[Effect of kagocel on the postradiation recovery of the hematopoiesis and immune status in mice exposed to ionizing radiation in sublethal dosage].
Copyright policy )[Effect of kagocel on the postradiation recovery of the hematopoiesis and immune status in mice exposed to ionizing radiation in sublethal dosage].
The efficiency of interferon inductor, kagocel, in hemopoiesis and immunity disturbances caused by sublethal doses of ionizing radiation was investigated. The experiments showed that irradiation of mice with a dose of 0.9 Gy causes short-term drop of a number of cells in the bone marrow and lymphoid organs, reducing of CFUs and CFU-GM levels, decrease in a number of antibody-formation cells in spleen and falling of reaction of blast-transformation of lymphocytes. The injection of kagocel 1 and 5 days after irradiation enhanced post-irradiation recovery of bone marrow hematopoiesis, stimulated compensatory potential of hematopoietic system and increase in antiviral resistance of irradiated animals.
Interferon Inducers, Gossypol, Lymphocyte Activation, Radiation Dosage, Hematopoiesis, Colony-Forming Units Assay, Mice, Radiation Injuries, Experimental, Orthomyxoviridae Infections, Influenza A virus, Immune System, Animals, Antibody-Producing Cells
Interferon Inducers, Gossypol, Lymphocyte Activation, Radiation Dosage, Hematopoiesis, Colony-Forming Units Assay, Mice, Radiation Injuries, Experimental, Orthomyxoviridae Infections, Influenza A virus, Immune System, Animals, Antibody-Producing Cells
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