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Il Giornale di Chiru...arrow_drop_down

Il Giornale di Chirurgia

Article . 1994

Data sources: Europe PubMed Central

Usiena air - Università di Siena

Article . 1994

Data sources: Usiena air - Università di Siena

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[Blood gastrin and colorectal neoplasms].

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1994 Italy Italian Journal:Il Giornale di chirurgia, volume 15 (issn: 0391-9005,

Authors: CIVITELLI, SERENELLA; Galgani P; Pacchiarotti MC; Civitelli B; Marini M; Pedani M; Bernini A; +1 Authors

pmid: 7946978

handle: 11365/42345

[Blood gastrin and colorectal neoplasms].

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Abstract

Gastrin has a trophic effect on the mucosa of the gastrointestinal tract and seems to have the potential for promoting colonic cancerogenesis through a chronic stimulation of the epithelial proliferation. Plasma gastrin has been reported to be elevated in patients with colorectal neoplasms. The aim of the present study was to verify this observation. Presurgical serum levels of gastrin were compared between 49 patients with colorectal neoplasms and 47 controls hospitalized for other surgical lesions. Results show significantly higher gastrin levels of case group than controls: 72.72 + 85.41 vs. 46.79 + 24.09 pg/ml (p < 0.05), and provide support for the hypothesis of a gastrin-stimulated neoplastic growth enhancing at the same time the potential therapeutic role of reducing gastrin secretion.

Country

Italy

Related Organizations

University of Siena
Italy

Keywords

Adenoma, Adult, Aged, 80 and over, Male, Carcinoma, Radioimmunoassay, Middle Aged, Gastrins, Humans, Female, Colorectal Neoplasms, Aged

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