Arachidonate lipoxygenase metabolite formation in gestational tissues.
Copyright policy )Arachidonate lipoxygenase metabolite formation in gestational tissues.
Products of arachidonic acid metabolism via the lipoxygenase pathways have a potential role in the onset of human labor. We have determined whether activation of protein kinase C can modulate the rate of biosynthesis within the uterus of five important arachidonate lipoxygenase metabolites, i.e., leukotriene B4 (LTB4), LTC4, 5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE and 15-HETE. Amnion, chorion laeve and decidual cells were isolated, grown to confluence and incubated with phorbol 12-myristate 13-acetate (PMA). PMA caused concentration-related stimulation of 5-HETE, 12-HETE and 15-HETE (but not LTB4) production; there were some stimulatory actions on decidual and amnion (but not chorion) LTC4 production. We postulate that activation of protein kinase C can result in enhanced production of arachidonate lipoxygenase metabolites that may have actions on the parturient process.
- University of Queensland Australia
- University of Utah United States
- University of Queensland Australia
Human Amnion Cells, Lipoxygenase, Arachidonate Lipoxygenases, Leukotriene B4, Pregnancy, Hydroxyeicosatetraenoic Acids, Decidua, Humans, Amnion, Inflammatory Mediators, Protein-kinase-c, Human Chorion Laeve, Phorbol Ester, Preterm Labor, Uterus, Decidual cells, 1103 Clinical Sciences, Chorion, Leukotriene C4, Prostaglandin Biosynthesis, Arachidonic acid, Primary Culture, 5-Hydroxyeicosatetraenoic Acid, 1114 Paediatrics and Reproductive Medicine, Human-Fetal Membranes, Female, Signal Transduction
Human Amnion Cells, Lipoxygenase, Arachidonate Lipoxygenases, Leukotriene B4, Pregnancy, Hydroxyeicosatetraenoic Acids, Decidua, Humans, Amnion, Inflammatory Mediators, Protein-kinase-c, Human Chorion Laeve, Phorbol Ester, Preterm Labor, Uterus, Decidual cells, 1103 Clinical Sciences, Chorion, Leukotriene C4, Prostaglandin Biosynthesis, Arachidonic acid, Primary Culture, 5-Hydroxyeicosatetraenoic Acid, 1114 Paediatrics and Reproductive Medicine, Human-Fetal Membranes, Female, Signal Transduction
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).6 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!