During a natural outbreak of edema disease in different farms 160 weaned piglets showing the clinical symptoms of palpebral edema, mental discomfort and apathy were selected and divided into three groups. The groups were treated as follows: Group 1 (51 piglets) received twice daily one i. m. dose of Gentamycin (11 mg/kg body weight), Prednisolone (1 mg/kg body weight), Melperone (4 mg/kg body weight) for 3 days. Group 2 (55 piglets) received twice daily one i. m. dose of Amphetaminum Phosphoricum 1 mg/kg body weight for 3 days. Group 3 (54 piglets) untreated control. The result showed that group 2 treated with stimulant of the central nervous system gave the best results concerning survival. It ist the authors opinion that concerning clinical symptoms and therapy further classification is necessary.