[Antimycobacterial acting carbazole derivatives].

Carbazoles are synthesized and tested for antimycobacterial properties (M. tuberculosis H 37 Ra, Middlebrook-7H9-broth). The different antimycobacterial properties of diastereomeres are examined using compounds 32 and 33, those of a racemic compound and the (+)-enantiomer are tested with (+/-)-12/(+)-12 and (+/-)-5/(+)-5, respectively. (+)-12 is prepared by enantioselective synthesis.

Related Organizations

University of Regensburg
Germany

Keywords

Antitubercular Agents, Carbazoles, Mycobacterium tuberculosis, Mycobacterium

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