The conception of radiosurgery now more than 40 years old is realized in clinical practice during last 25 years. There were elaborated 3 main methods: focused irradiation by gamma knife, by accelerated heavy charged particles and by linear accelerator. The results led radiosurgery spread over the world. The main indications are vascular malformations (44%), benign intracranial tumours (33%), malignant tumours including metastasis (21%) and functional disorders (2%). The pathological lesions can be controlled or liquidated in 80-95%. The hospital story is minimal, 1-2 days, and there is no risk of mortality and morbidity is minimal. Only the time of healing is prolonged to some years with indispensable follow-up. Further technical improvement and growing number of patients treated by radiosurgery can be expected.