Some neurologic syndromes are often associated with neoplasm, as a paraneoplastic disorder. Among them, namely, subacute cerebellar degeneration, sensory neuronopathy, dermatomyositis/polymyositis, Lambert-Eaton myasthenic syndrome and subacute motor neuronopathy, prove sooner or later to be harbouring a neoplasm, therefore a thorough clinical evaluation should be carried out to identify the primary tumour site. The AA present a brief review of these neurologic syndromes, illustrating the first three mentioned with clinical cases. A reference is made to the immunological associated aspects and their clinical importance.