[Decreased anaphylactogenic properties of disaggregated gamma-globulin].

B N, Sofronov; T G, Shemerovskaia

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Bulletin of Experimental Biology and Medicine

Article . 1978

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[Decreased anaphylactogenic properties of disaggregated gamma-globulin].

descriptionPublicationkeyboard_double_arrow_right Article 28 Aug 1978 Russian Journal:Biulleten' eksperimental'noi biologii i meditsiny, volume 85 (issn: 0365-9615,

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Authors: B N, Sofronov; T G, Shemerovskaia;

pmid: 77692

[Decreased anaphylactogenic properties of disaggregated gamma-globulin].

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Abstract

Immunological properties of native, aggregated, and disaggregated (tolerogenic) human gamma-globulin were compared in experiments on mice and guinea pigs. Disaggregated preparation was shown to give diminished local and general hypersensitivity reaction in sensitized animals and had decreased ability to induce secondary humoral immune response.

Keywords

Drug Hypersensitivity, Mice, Protein Denaturation, Guinea Pigs, Immune Tolerance, Immunity, Mice, Inbred CBA, Animals, Humans, Immunization, gamma-Globulins, Anaphylaxis

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