
Drug resistance is a frequent clinical event, induced by more than one mechanism. It is intrinsic and/or acquired by tumoral cell population. But the failure of chemotherapy is also associated to intratumoral drug incorporation and altered drug and/or cell metabolism. Prevention of drug resistance needs integration of pharmacokinetic, biochemical and pathological characteristics of tumoral cell population.
Neoplasms, Research, Drug Resistance, Humans, Antineoplastic Agents
Neoplasms, Research, Drug Resistance, Humans, Antineoplastic Agents
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