Isolation and identification of tetrahydrocolumbamine as a dopamine receptor ligand from Polygala tenuifolia Willd.
Copyright policy )Isolation and identification of tetrahydrocolumbamine as a dopamine receptor ligand from Polygala tenuifolia Willd.
The isolation and purification of a dopamine receptor ligand, tetrahydrocolumbamine from Polygala tenuifolia Willd is described. Tetrahydrocolumbamine was shown to inhibit the binding of [3H]-SCH23390 and [3H]-spiroperidol to rat striatum membranes in vitro with IC50 values of 0.75 +/- 0.08 mumol.L-1 and 0.92 +/- 0.10 mumol.L-1, respectively. The compound inhibited the binding of [3H]-prazosin (IC50 value of 46 mumol.L-1), while it did not change the binding of the ligands, [3H]-QNB and [3H]-muscimol to rat cortex in vitro. Scatchard plot analysis showed a mixture of competitive and non-competitive inhibition by the compound on both [3H]-SCH23390 and [3H]-spiroperidol binding to membranes from rat striatum.
Male, Berberine Alkaloids, Cell Membrane, Prazosin, Benzazepines, Binding, Competitive, Corpus Striatum, Rats, Receptors, Dopamine, Spiperone, Animals, Rats, Wistar, Drugs, Chinese Herbal
Male, Berberine Alkaloids, Cell Membrane, Prazosin, Benzazepines, Binding, Competitive, Corpus Striatum, Rats, Receptors, Dopamine, Spiperone, Animals, Rats, Wistar, Drugs, Chinese Herbal
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