Anti-fertility activity and hormonal profile of trans-anethole in rats.
Copyright policy )Anti-fertility activity and hormonal profile of trans-anethole in rats.
Trans-anethole was studied for antifertility activity in rats at dose levels of 50 mg, 70 mg and 80 mg/kg po. Dose-dependent activity was observed, a 100% anti-implantation activity being achieved at 80 mg/kg, po. The compound showed a significant estrogenic activity and did not possess anti-estrogenic, progestational, anti-progestational, androgenic or anti-androgenic activities. In an earlier study, the compound was found to be safe, its LD50 being more than 3000 mg/kg, po in mice.
Male, Dose-Response Relationship, Drug, Estradiol, Ovariectomy, Prostate, Seminal Vesicles, Abortion, Induced, Allylbenzene Derivatives, Estrogens, Organ Size, Anisoles, Rats, Lethal Dose 50, Fertility, Pregnancy, Animals, Female, Testosterone, Contraceptives, Oral
Male, Dose-Response Relationship, Drug, Estradiol, Ovariectomy, Prostate, Seminal Vesicles, Abortion, Induced, Allylbenzene Derivatives, Estrogens, Organ Size, Anisoles, Rats, Lethal Dose 50, Fertility, Pregnancy, Animals, Female, Testosterone, Contraceptives, Oral
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