The study deals with the bone-prosthesis interface using an in vivo experimental animal model in relation to loading and walking on the prosthetized hip, studied by force plate analysis. The interface is studied from a histological and morphometric point of view by means of a LECO 2001 system. Results show that titanium favors osteointegration according to the criteria of Branemark even in conditions of physiological loading; bone ingrowth (that cannot be considered a true process of osteointegration) was 27.6%; furthermore, we quantified two models of periprosthetic bone growth in an osteointegrative sense: total bone bonding (27.4%) and core bone bonding (bone that grows in direct contact with the prosthesis) that was 16.1%. Finally, osteointegration tends to be greater where contact between the bone and the prosthetic is closer, regardless of the type of prosthetic coating.