A unique chromosome translocation, t(11;12;18)(q21;q13;q21) [correction of t(11;12;18)(q13;q13;q12)], in primary lung lymphoma.

I, Kubonishi; S, Sugito; M, Kobayashi; Y, Asahi; T, Tsuchiya; T, Yamashiro; I, Miyoshi

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Cancer Genetics and ...arrow_drop_down

Cancer Genetics and Cytogenetics

Article . 1995

Data sources: Europe PubMed Central

A unique chromosome translocation, t(11;12;18)(q21;q13;q21) [correction of t(11;12;18)(q13;q13;q12)], in primary lung lymphoma.

descriptionPublicationkeyboard_double_arrow_right Article 05 Sep 1995 English Journal:Cancer genetics and cytogenetics, volume 82 (issn: 0165-4608,

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Authors: I, Kubonishi; S, Sugito; M, Kobayashi; Y, Asahi; T, Tsuchiya; T, Yamashiro; I, Miyoshi;

pmid: 7627935

A unique chromosome translocation, t(11;12;18)(q21;q13;q21) [correction of t(11;12;18)(q13;q13;q12)], in primary lung lymphoma.

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Abstract

A 54-year old man with a primary lung lymphoma of mucosa-associated lymphoid tissue (MALT) origin whose tumor cells had a t(11;12;18)(q13;q13;q12) chromosome abnormality is described. The morphologic, immunologic, and molecular biologic investigations showed that the patient's lung tumor consisted of small lymphoid cells that expressed monoclonal IgM, kappa-type immunoglobulin, and immunoglobulin gene (JH and C kappa) rearrangements. Cytogenetic study revealed that the tumor cells contained a unique chromosome translocation, t(11;12;18)(q13;q13;q12), that has not been reported previously in lymphoma.

Related Organizations

Kochi Medical School Hospital
Japan

Keywords

Chromosome Aberrations, Male, Chromosomes, Human, Pair 12, Lung Neoplasms, Lymphoma, Chromosomes, Human, Pair 11, Chromosome Disorders, Middle Aged, Translocation, Genetic, Humans, Chromosomes, Human, Pair 18

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