Nine patients with open wounds are reviewed. All wounds were debrided prior to application of Biobrane. Silver sulfadiazine was applied twice daily. All healed uneventfully after closure. Biobrane is recommended for treatment of difficult and large open wounds; its use reduces evaporative loss and bacterial proliferation, enabling development of a healthy wound base suitable for grafting or delayed closure. This approach can prevent the necessity for flap repair and reduce pain during wound dressing. Wounds such as lower extremity ulcers are often resistant to therapy. Repeated debridements may result in further desiccation without progression of wound healing. Biobrane-treated wounds develop a healthy granulating base which can be grafted or closed.