[BCG vs. BCG plus recombinant alpha-interferon 2b in superficial tumors of the bladder].

E, Bercovich; M, Deriu; F, Manferrari; G, Irianni

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Archivio Italiano di Urologia e Andrologia

Article . 1995

Data sources: Europe PubMed Central

[BCG vs. BCG plus recombinant alpha-interferon 2b in superficial tumors of the bladder].

descriptionPublicationkeyboard_double_arrow_right Article 08 Dec 1995 Italian Journal:Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, volume 67 (issn: 1124-3562,

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Authors: E, Bercovich; M, Deriu; F, Manferrari; G, Irianni;

pmid: 7581527

[BCG vs. BCG plus recombinant alpha-interferon 2b in superficial tumors of the bladder].

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Abstract

BCG intravesical instillation is a well established therapy for superficial bladder carcinoma as adjuvant and/or prophylactic treatment. However side-effects are frequent when full doses are employed and therefore low dose alternative schedules were proposed. Interferon intraluminal therapy for bladder TCC has been used with similar indication but the results did not encourage further single drug trials. A double arm random study, BCG full dose vs. BCG low dose, is presented. The results point out that the combination treatment is superior to BCG full dose therapy in terms of side effects and similar to BCG full dose as regards efficiency (5/18 vs 4/18 recurrences) after a follow-up of 24.11 +/- 8.15 for BCG and 16.72 +/- 8.7 for BCG + IFN.

Related Organizations

University of Sassari
Italy

Keywords

Carcinoma, Interferon-alpha, Interferon alpha-2, Middle Aged, Recombinant Proteins, Administration, Intravesical, Urinary Bladder Neoplasms, Data Interpretation, Statistical, BCG Vaccine, Humans, Neoplasm Recurrence, Local, Aged

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