A neutral sugar is responsible for serovar specificity of the antigenic determinant of Leptospira interrogans serovar canicola.

descriptionPublicationkeyboard_double_arrow_right Article 31 Aug 1994 Japan English Publisher:The Graduate School of Veterinary MedicineJournal:The Japanese journal of veterinary research, volume 42 (issn: 0047-1917,

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Authors: KASHIWASE, Hiroto; ONO, Etsuro; YANAGAWA, Ryo; SHIMIZU, Yukio; KIDA, Hiroshi;

pmid: 7528287

handle: 2115/2471

A neutral sugar is responsible for serovar specificity of the antigenic determinant of Leptospira interrogans serovar canicola.

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Abstract

To provide information on the chemical structures of antigenic determinants of leptospira, glycolipids of Leptospira interrogans serovar canicola strain Hond Utrecht IV (Ut-IV) and its antigenic variant selected in the presence of a serovar-specific monoclonal antibody were compared physicochemically. Gas-liquid chromatography-mass spectrometry analysis revealed that the glycolipid of Ut-IV contained 6 neutral sugar species; rhamnose, mannose, galactose, glucose, and unknown sugars III and IV, in addition to unknown sugars I and II that had been previously reported. On the other hand, the glycolipid of the variant lacked unknown sugar III, suggesting that this sugar is responsible for the serovar-specific antigenic determinant.

Country

Japan

Related Organizations

Hokkaido Bunkyo University
Japan
Hokkaido University
Japan

Keywords

Leptospira, Antigens, Bacterial, Carbohydrates, Antibodies, Monoclonal, Genetic Variation, Oligosaccharides, determinant, Gas Chromatography-Mass Spectrometry, Epitopes, Mice, antigen, sugar, 649, Animals, Glycolipids, Leptospira interrogans, glycolipid

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