This article reports our experience with lyophilized human dura in the treatment of complex urethral stenosis.Seven patients with iatrogenic/inflammatory urethral stricture underwent a 13 cms long x 1.5 cms wide medial urethral augmentation.During a mean follow-up of 23 months, good results accounted for 85.7%.Lyophilized dura patches constitute a suitable choice in selected patients who, for local or systemic reasons, are not good candidates for other urethroplasty procedures.