[Action of actinomycin and alpha-amanitin on the RNA transcription of the influenza virus].
Copyright policy [Action of actinomycin and alpha-amanitin on the RNA transcription of the influenza virus].
Complete (template RNA) and incomplete (messenger RNA) transcripts were separated by electrophoretic fractionation of RNA-hybrids containing unlabeled genome RNA of influenza virus and virus-specific antigenome 3H-RNAs obtained from infected cells. Incubation of the infected cells in the presence of actinomycin D or alpha-amanitine was shown to inhibit selectively viral mRNA synthesis. It is suggested that the synthesis of mRNA and template antigenome RNA of influenza virus is initiated by different mechanisms.
Amanitins, Transcription, Genetic, Influenza A virus, Depression, Chemical, Dactinomycin, Animals, RNA, Viral, Chick Embryo, RNA, Messenger
Amanitins, Transcription, Genetic, Influenza A virus, Depression, Chemical, Dactinomycin, Animals, RNA, Viral, Chick Embryo, RNA, Messenger
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