[5'-deoxy-5-fluoruridine, a new antineoplastic pyrimidine antimetabolite].
Copyright policy )[5'-deoxy-5-fluoruridine, a new antineoplastic pyrimidine antimetabolite].
5'-deoxy-5-fluorouridine (5-DFUR) exerts a marked cytostatic activity, both intraperitoneally and orally, against experimental tumors. It has a strong antitumor effect on the Crocker sarcoma S 180, the Lewis lung carcinoma and a chemically induced squamous cell carcinoma of the skin. Its ratio of antitumor activity toxicity is more favourable than that of 5-fluorouracil, 2'-deoxy-5-fluorouridine and 1-(2-tetra-hydrofuryl)-5-fluorouracil. Mode of action and reasons for the favourable therapeutic ratio are discussed.
Antimetabolites, Antineoplastic, Mice, Lung Neoplasms, Pyrimidines, Skin Neoplasms, Carcinoma, Squamous Cell, Animals, Fluorouracil, Sarcoma 180
Antimetabolites, Antineoplastic, Mice, Lung Neoplasms, Pyrimidines, Skin Neoplasms, Carcinoma, Squamous Cell, Animals, Fluorouracil, Sarcoma 180
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